Related Experiment Video

Updated: May 18, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic

Simon B Drysdale1, Anthony D Milner, Anne Greenough

  • 1Division of Asthma, Allergy and Lung Biology, the MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|September 12, 2012
PubMed

Insights

Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infants can lead to long-term breathing problems. Genetic factors, like specific gene polymorphisms, may increase the risk of developing wheeze after RSV LRTI in newborns.

Area of Science:

  • Pediatric respiratory medicine
  • Immunogenetics
  • Epidemiology of infectious diseases

Background:

  • Infant respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) is a significant cause of chronic respiratory morbidity.
  • Premorbid abnormal lung function may increase susceptibility to RSV LRTI in premature infants.

Purpose of the Study:

  • To investigate genetic predispositions to respiratory morbidity following RSV LRTI.
  • To identify specific gene polymorphisms associated with wheeze development post-RSV LRTI in term-born infants.

Main Methods:

  • Systematic literature review of studies on RSV LRTI and subsequent respiratory outcomes.
  • Analysis of genetic associations, focusing on single-nucleotide polymorphisms (SNPs) in immune-related genes.

Main Results:

  • Specific polymorphisms in genes such as IL-8, IL-19, IL-20, IL-13, mannose-binding lectin, IFNG, and RANTES were associated with wheeze.
  • These genetic variations appear to influence the risk of developing chronic respiratory issues after RSV infection in infancy.

Conclusions:

  • Genetic factors play a role in the development of post-RSV LRTI wheeze in term-born infants.
  • Identifying these genetic markers could aid in predicting and potentially preventing chronic respiratory morbidity in infants following RSV infection.
Abstract

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...