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Related Experiment Video

Updated: May 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Infantile bullous pemphigoid].

M Barreau¹, A Stefan, J Brouard

¹UFR de médecine, service de dermatologie, université de Caen Basse-Normandie, centre hospitalier universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex 9, France. morgane-barreau@orange.fr

Annales De Dermatologie Et De Venereologie

|September 12, 2012

Summary

Bullous pemphigoid (BP) is rare in children but can occur after vaccination. This infant case showed palmoplantar lesions and resolved with treatment, with no recurrence after continuing the vaccination schedule.

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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Published on: June 17, 2025

Area of Science:

Pediatric Dermatology
Autoimmune Bullous Diseases
Vaccine Safety

Background:

Bullous pemphigoid (BP) is a rare autoimmune blistering disease in children, with limited documented cases post-vaccination.
This report details a novel case of BP in an infant following initial vaccinations.

Observation:

A 3-month-old infant developed a bullous eruption on palms and soles two weeks after receiving Infanrix Quinta and Prevenar.
Histopathology and direct immunofluorescence confirmed features typical of BP, including dermal-epidermal cleavage and IgG/C3 deposits.

Findings:

Childhood BP presents differently than adult BP, with a higher incidence of palmoplantar lesions in infants.
The study found no evidence implicating vaccines in the BP outbreak, as the vaccination schedule was safely continued without recurrence.
Childhood BP is generally benign and resolves within a year with corticosteroid treatment.

Implications:

Pediatricians should consider childhood bullous pemphigoid in infants presenting with blistering, especially on the palms and soles.
Current data suggest vaccines are not contraindicated in children with or at risk for BP.
Further research is needed to understand the potential, though hypothetical, link between vaccinal antigens and BP onset.