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Related Experiment Video

Updated: May 18, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Sellar xanthogranuloma.

Isabel Pavón de Paz1, David Peñalver Talavera, Juana Olivar Roldán

  • 1Servicio de Endocrinología. Hospital Universitario de Getafe. Getafe. Madrid. España.

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|September 12, 2012
PubMed
Summary

A rare pituitary lesion, xanthogranuloma of the sella turcica, was diagnosed in a young woman after a decade. This diagnosis was supported by its unique clinical progression and successful surgical removal.

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Last Updated: May 18, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • A 16-year-old female presented with idiopathic precocious puberty and normal pituitary imaging.
  • Ten years later, worsening headaches prompted a new MRI revealing a pituitary lesion.

Purpose of the Study:

  • To diagnose a rare pituitary lesion presenting with delayed onset and unusual symptoms.
  • To differentiate between craniopharyngioma and xanthogranuloma of the sella turcica.

Main Methods:

  • Serial cranial magnetic resonance imaging (MRI) scans.
  • Glucocorticoid administration and monitoring for side effects.
  • Surgical intervention and histopathological examination of the resected lesion.

Main Results:

  • A pituitary lesion, initially undetected, was identified 10 years after initial evaluation.
  • Headaches improved with glucocorticoids, but steroid psychosis developed as a complication.
  • Surgical removal was successful, with preservation of pituitary and visual functions.
  • Pathological findings supported xanthogranuloma of the sella turcica over craniopharyngioma, with no recurrence.

Conclusions:

  • Xanthogranuloma of the sella turcica is a rare pituitary tumor that can present with delayed onset.
  • The clinical course, surgical outcomes, and lack of recurrence strongly favor xanthogranuloma over craniopharyngioma in this case.
  • This case highlights the importance of considering xanthogranuloma in the differential diagnosis of sellar lesions.