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Continuous glucose monitoring in insulin pump treated children

Emilio García-García1, Raúl Sánchez-Pérez, Rafael Galera

  • 1Unidad de Endocrinología Pediátrica. Complejo Hospitalario Torrecárdenas. Almería. España.

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|September 12, 2012
PubMed

Insights

Continuous glucose monitoring in children with type 1 diabetes on insulin pumps showed irregular glucose levels and frequent hyperglycemia. The continuous glucose monitoring system (CGMS) was generally well tolerated, preserving hypoglycemia symptoms.

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Technology
  • Metabolic Disorders

Background:

  • Insulin pump therapy is a key strategy for managing type 1 diabetes (T1D) in children and adolescents.
  • The goal of insulin pump therapy is to optimize glycemic control and minimize hypoglycemia.
  • Continuous glucose monitoring systems (CGMS) offer detailed insights into glucose fluctuations.

Purpose of the Study:

  • To evaluate interstitial glucose levels in pediatric T1D patients using insulin pumps.
  • To assess the frequency, duration, and symptoms of hypo- and hyperglycemia via CGMS.
  • To determine the tolerability of CGMS in this patient population.

Main Methods:

  • A cohort of thirteen children and adolescents with T1D on insulin pump therapy was studied.
  • Continuous glucose monitoring (CGMS) was employed for 72 hours to track interstitial glucose.
  • Patient demographics included age, diabetes duration, pump therapy duration, insulin dosage, and HbA1c levels.

Main Results:

  • Interstitial glucose concentrations averaged 187±40 mg/dl, indicating suboptimal glycemic control.
  • Hyperglycemia (above 180 mg/dl) was present for 47.3%±17.4% of the time.
  • Hypoglycemia (below 70 mg/dl) occurred 3.6%±5.6% of the time, with preserved adrenergic symptoms.

Conclusions:

  • Children and adolescents with T1D on insulin pumps exhibit irregular interstitial glucose levels and do not achieve normoglycemia.
  • Adrenergic symptoms of hypoglycemia remain intact in this population.
  • The CGMS was generally well tolerated by the pediatric patients, with one exception.
Abstract

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