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Published on: October 29, 2014
Clinical recovery of chronic intestinal pseudo-obstruction with cisapride in a complex pediatric patient
Jean-Christy F Cameron1, Régis Vaillancourt, Nathalie Major-Cook
1School of Pharmacy, University of Waterloo, Waterloo, ON, Canada.
Insights
Cisapride effectively treated pediatric intestinal pseudo-obstruction, improving symptoms and feeding tolerance without adverse effects. This offers a promising therapeutic option for children with this rare condition.
Area of Science:
- Pediatric Gastroenterology
- Pharmacology
Background:
- Chronic intestinal pseudo-obstruction (CIP) significantly impacts pediatric patients.
- Limited effective therapeutic options exist for pediatric CIP.
- Paucity of literature on CIP treatment in children.
Abstract:
Cisapride is a gastrointestinal prokinetic that facilitates or restores motility along the entire gastrointestinal tract. It has been used successfully to treat acute and chronic intestinal pseudo-obstructions (CIPs) in adults, but there is a paucity of literature surrounding the treatment of CIP in pediatric patients and therapies for CIP are limited and their impact is often unsatisfactory. This case report presents the use of cisapride in the management of pseudo-obstruction. Treatment with cisapride substantially improved the patient's symptoms and improved feeding tolerance. It improved his prognosis remarkably and prevented the need for end-of-life care. He experienced no adverse effects throughout the course of therapy. The treatment regimen is discussed in this case report.
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