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Updated: May 18, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Atypical onset cryoglobulinemia: case report]
M Consolo1, A Amoroso, G D'Amico
1Dipartimento di Scienze Bio-mediche, Università degli Studi di Catania, Italia. maria.consolo.ct@gmail.com
Cryoglobulinemia, a condition involving antibody precipitation, can present atypically. This case highlights that clinical symptoms may precede laboratory confirmation of cryoglobulins.
Area of Science:
- Immunology
- Rheumatology
- Internal Medicine
Background:
- Cryoglobulinemia involves antibodies precipitating below 37°C, leading to immune complex-mediated vasculitis.
- It presents as primary (essential mixed cryoglobulinemia) or secondary forms, often linked to HCV infection.
- Clinical severity doesn't always correlate with cryoglobulin or immune complex serum levels.
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