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Related Experiment Video

Updated: May 18, 2026

Gene Editing of Primary Rhesus Macaque B Cells
09:53

Gene Editing of Primary Rhesus Macaque B Cells

Published on: February 10, 2023

RhesusBase: a knowledgebase for the monkey research community.

Shi-Jian Zhang1, Chu-Jun Liu, Mingming Shi

  • 1Institute of Molecular Medicine, Peking University, Beijing, China.

Nucleic Acids Research
|September 12, 2012
PubMed
Summary

RhesusBase enhances biomedical research by correcting over 28% of mis-annotated rhesus macaque gene structures. This new resource provides accurate gene models and functional annotations for the primate research community.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Primate Research

Background:

  • Rhesus macaques are valuable models for human disease research.
  • Current gene structures and annotations are error-prone, limiting their utility.
  • Accurate genomic data is crucial for advancing translational studies.

Purpose of the Study:

  • To develop an accurate and comprehensive genomic resource for rhesus macaques.
  • To correct mis-annotated gene structures and improve transcript annotations.
  • To create a user-friendly database for the research community.

Main Methods:

  • Performed strand-specific RNA-Sequencing on 10 macaque tissues.
  • Generated 1.2 billion 90-bp paired-end reads.
  • Integrated functional genomics annotations from over 60 resources.

Main Results:

  • Identified and corrected mis-annotations in at least 28.7% of macaque transcripts.
  • Revised gene models show improved exon-intron boundaries and UTRs.
  • Corrected 1292 exon-intron boundaries in coding exons, refining open reading frames.
  • Developed RhesusBase, an online database with visualization and download capabilities.

Conclusions:

  • RhesusBase significantly improves the accuracy of rhesus macaque gene annotations.
  • The database provides a vital 'one-stop' resource for primate research.
  • Enhanced genomic data will accelerate translational studies of human diseases.