Related Experiment Video
Updated: May 18, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Tocilizumab for giant cell arteritis: an amazing result
Metin Işık1, Levent Kılıç, İsmail Doğan
1Division of Rheumatology, Department of Internal Medicine, Hacettepe University Hospital, Sihhiye, 06100, Ankara, Turkey, metin1721978@yahoo.com.
Giant cell arteritis (GCA) is a large artery vasculitis. A case resistant to standard treatments was successfully managed with tocilizumab, offering a new therapeutic option.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Giant cell arteritis (GCA), or Horton's disease, is a systemic vasculitis affecting medium-to-large arteries.
- It primarily impacts individuals over 50 years old.
- Glucocorticoids are the standard treatment for GCA.
Observation:
- This report details a patient with GCA refractory to multiple therapies.
- The patient had failed oral and intravenous steroids, cyclophosphamide, and mycophenolate mofetil.
Findings:
- Successful treatment of steroid-refractory GCA was achieved using tocilizumab.
- Tocilizumab, an interleukin-6 receptor inhibitor, demonstrated efficacy in this resistant case.
Implications:
- Tocilizumab represents a potential alternative therapy for refractory GCA cases.
- This finding may guide future treatment strategies for patients unresponsive to conventional GCA management.
More Related Videos
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)