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Updated: May 18, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
A novel method for the labelling of peptides and proteins through a bioorthogonal Staudinger reaction by using
Matthew C Uzagare1, Iris Claussnitzer, Michael Gerrits
1Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany.
Abstract:
Chemoselective modification of biomolecules: The reaction between 2-cyanoethyl phosphoramidites and azides is economical and can be performed in different solvents, including aqueous buffers. The course of the reaction with azido-modified amino acids, peptides or proteins and different label molecules was followed by (31)P NMR spectroscopy.
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