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Adenosine increases nasal mucociliary clearance rate in mice through A2A and A2B adenosine receptors

Xiaoyang Hua1, Warren C Naselsky, William D Bennett

  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7219, USA. xiaoyang_hua@med.unc.edu

The Laryngoscope
|September 12, 2012
PubMed
Abstract

Insights

Adenosine enhances nasal mucociliary clearance (MCC) by activating A(2A) and A(2B) receptors. Targeting these receptors may offer new treatments for chronic rhinosinusitis (CRS) by improving MCC.

Area of Science:

  • Respiratory physiology
  • Pharmacology
  • Immunology

Background:

  • Mucociliary clearance (MCC) is a crucial respiratory defense mechanism.
  • Impaired MCC is implicated in chronic rhinosinusitis (CRS).
  • Adenosine's role in nasal MCC requires elucidation.

Purpose of the Study:

  • To investigate the effect of adenosine on nasal MCC in vivo.
  • To identify the specific adenosine receptors involved in regulating nasal MCC.

Main Methods:

  • A prospective animal study utilizing a mouse model.
  • Nasal MCC was quantified using whole-nose scintigraphy.
  • Adenosine's effects were assessed in wild-type and various adenosine receptor knockout mice (A(2A)(-/-), A(2B)(-/-), A(2A)(-/-)A(2B)(-/-), A(1)(-/-)A(3)(-/-)).

Main Results:

  • Adenosine aerosol significantly increased nasal MCC.
  • This enhancement was abolished in mice lacking both A(2A) and A(2B) receptors.
  • Basal MCC was reduced in mice lacking both A(2A) and A(2B) receptors.

Conclusions:

  • Activation of both A(2A) and A(2B) adenosine receptors accelerates nasal MCC.
  • Targeting these G(s)-coupled receptors presents a potential therapeutic strategy for CRS.
  • Enhancing MCC via adenosine receptor modulation could benefit CRS patients.

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