Related Experiment Video
Updated: May 18, 2026
09:54
Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
Published on: May 22, 2020
Prolonged fever after Infliximab infusion
1Jennifer Katz, Michael Frank, New York University Medical Center, New York, NY 10016, United States.
World Journal of Gastrointestinal Pharmacology and Therapeutics
|September 12, 2012
Summary
Anti-tumor necrosis factor (TNF) therapy, like Infliximab, is used for severe ulcerative colitis (UC). This case highlights a prolonged fever reaction following Infliximab treatment in a patient with steroid-refractory UC.
Area of Science:
- Gastroenterology
- Immunology
- Pharmacology
Background:
- Ulcerative colitis (UC) management now includes anti-tumor necrosis factor (TNF) therapies for severe cases.
- Infliximab, a monoclonal antibody targeting TNF-α, is a key therapy.
- Potential adverse events include infections, malignancy, autoimmune conditions, and infusion reactions.
Purpose of the Study:
- To report a case of prolonged fever after Infliximab infusion.
- To highlight a specific adverse reaction in the context of treating steroid-refractory ulcerative colitis.
Main Methods:
- Case report of a patient with steroid-refractory ulcerative colitis.
- Administration of Infliximab for treatment.
- Monitoring for adverse reactions, specifically prolonged fever.
Main Results:
- The patient experienced a prolonged fever after Infliximab infusion.
- This reaction occurred in the context of treating severe, steroid-refractory UC.
Conclusions:
- Prolonged fever is a potential complication of Infliximab therapy.
- Careful monitoring for adverse events is crucial in patients receiving anti-TNF agents for UC.
Related Concept Videos
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:25Increased Body Temperature
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
01:26Patterns of Fever
Before understanding the types and patterns of fever, it is essential to know its phases.
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...