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Updated: May 18, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Epigenetic-dependent regulation of drug transport and metabolism: an update
Marina Kacevska1, Maxim Ivanov, Magnus Ingelman-Sundberg
1Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Abstract:
The pharmacokinetics of a drug are subject to large interindividual variability, which can result in lack of response or adverse drug reactions. In addition to genetic polymorphisms and drug interactions, key genes involved in the metabolism and transport of drugs are demonstrated to have epigenetic influences that can potentially affect interindividual variability in drug response. Emerging studies have focused on the importance of DNA methylation for ADME gene expression and for drug action and resistance, particularly in cancer. However, the epigenetic and ncRNA-dependent regulation of these genes, as well as the pharmacological consequences, is in need of greater attention. In the current review we provide an update of epigenetic and ncRNA-dependent regulation of ADME genes.
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