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Related Experiment Video

Updated: May 18, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance.

John Rojas¹, Ira Buckner, Vijay Kumar

¹School of Pharmaceutical Chemistry, University of Antioquia, Medellin, Colombia. jrojasca@gmail.com

Drug Development and Industrial Pharmacy

|September 13, 2012

Summary

Advanced co-processed excipients improve drug formulation by enhancing functional properties. This overcomes limitations of traditional excipients for direct compression tablet manufacturing, enabling higher drug loads and better tablet quality.

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Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Delivery

Background:

Emerging active pharmaceutical ingredients (APIs) often exhibit poor mechanical properties and low aqueous solubility.
Approximately 80% of current drugs are unsuitable for direct compression due to limitations of conventional excipients.
High-speed rotary tablet presses demand excipients with superior flow, compressibility, compactibility, particle size distribution, and homogeneity.

Purpose of the Study:

To describe and discuss the enhancement of functional properties of commercial and investigational excipients through co-processing.
To highlight the benefits of co-processed excipients in overcoming limitations for direct compression tablet manufacturing.

Main Methods:

Co-processing: A physical process combining two or more excipients to create multifunctional materials.
Evaluation of enhanced functional properties including flow, compressibility, compactibility, and particle characteristics.
Assessment of the impact on drug formulation and tabletability.

Main Results:

Co-processed excipients demonstrate significantly enhanced functional properties compared to conventional grades.
These advanced excipients are suitable for direct compression, offering high dilution potential and accommodating higher drug loads (up to 50%).
Co-processing effectively addresses the drawbacks of individual excipients, leading to improved tablet properties.

Conclusions:

Co-processing is a viable strategy to develop advanced excipients with superior functionality for modern pharmaceutical manufacturing.
The use of co-processed excipients facilitates direct compression, reduces formulation complexity, and improves tablet quality.
This approach is crucial for formulating emerging APIs with challenging physicochemical properties.