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Updated: May 18, 2026

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
Published on: June 16, 2022
New insights into pre-mRNA processing factor 19: A multi-faceted protein in humans
Jie Yin1, Ji-Min Zhu, Xi-Zhong Shen
1Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Abstract:
During the dynamic assembly and activation of the spliceosome, human pre-mRNA processing factor 19 (hPrp19) plays a major role alone or as a part of a protein complex. In addition to participating in post-transcriptional regulation of eukaryotic gene, hPrp19 takes part in many physiological events such as ubiquitin-proteasome system, DNA damage response, proliferation and apoptosis. Increasing evidence also indicates a potential role of hPrp19 during oncogenesis, possibly owing to its activity of repressing apoptosis. Together, these studies add a new dimension to our understanding of hPrp19, and we have reason to believe that continuing excavation of this multi-faceted protein may shed light on its roles in human diseases, especially in cancer.
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