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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 18, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Recent advances in platelet proteomics.

Michela Di Michele1, Chris Van Geet, Kathleen Freson

  • 1Center for Molecular and Vascular Biology, UZ-Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

Expert Review of Proteomics
|September 13, 2012
PubMed
Summary

Proteomics advances enhance understanding of platelet function in health and disease. This research reviews techniques identifying platelet proteins for new diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hematology

Background:

  • Platelets are crucial for primary hemostasis and implicated in various pathological conditions.
  • Proteomic methodologies have significantly advanced the understanding of platelet biology and disease mechanisms.
  • Platelet proteomics aids in identifying molecular mechanisms of disorders and discovering biomarkers.

Purpose of the Study:

  • To review common and innovative proteomic techniques applied to platelet research.
  • To highlight subproteomic strategies for analyzing specific platelet conditions, compartments, or fractions.
  • To underscore the value of proteomic discoveries for basic science and clinical applications.

Main Methods:

  • Review of gel-based and gel-free proteomic techniques.

More Related Videos

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Related Experiment Videos

Last Updated: May 18, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

  • Focus on subproteomic strategies (e.g., membrane, granule, microparticle analysis).
  • Examination of specific fractions like phosphoproteome and glycoproteome.

    • Main Results:

    • Thousands of platelet proteins and interactions have been identified through various proteomic approaches.
    • Proteomics provides insights into both normal platelet physiology and disease-associated alterations.
    • Subproteomic strategies enable detailed analysis of specific platelet components and states.

    Conclusions:

    • Proteomic studies have greatly expanded the knowledge of platelet biology.
    • Identified platelet proteins and interactions offer potential for novel diagnostic biomarkers and drug targets.
    • This comprehensive review serves as a valuable resource for researchers and clinicians in platelet biology.