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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for

M Pilar Gil1, Mickaël J Y Ploquin, Wendy T Watford

  • 1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02903, USA.

Blood
|September 13, 2012
PubMed
Summary

Type 1 interferons (IFNs) activate STAT4 over STAT1 in CD8 T cells during viral infections. STAT4 promotes T cell expansion and resistance to IFN-induced proliferation inhibition.

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