Assessment of diastolic filling indexes obtained by radionuclide ventriculography

This study assesses how differences in residual volume and heart rate influence the measurement and interpretation of commonly used indexes of left ventricular filling obtained by radionuclide ventriculography. Thirty patients with hypertrophic cardiomyopathy (HC) and 26 normal subjects were studied. The time to peak filling rate (168 +/- 42 vs 139 +/- 35 ms; p = 0.006) and time to 30% filling (154 +/- 32 vs 131 +/- 29 ms; p = 0.009 were prolonged in patients with HC compared to normal subjects, suggesting impaired early diastolic filling. However the peak filling rate, measured in end-diastolic counts/s, was greater in patients with HC (3.31 +/- 0.89 vs 3.06 +/- 0.51, p = 0.19). This measurement was influenced by the relative residual volume (HC r = 0.41, p less than 0.001; normal r = 0.29, difference not significant), which was smaller in patients with HC (22.4 +/- 8.0 vs 35.5 +/- 5.6%; p less than 0.0001). The peak filling rate measured in stroke volume counts did not vary with the relative residual volume (HC r = 0.10, difference not significant; normal r = 0.21, difference not significant) and was less than normal in patients with HC (4.27 +/- 0.69 vs 4.72 +/- 1.0; p = 0.58). There was a strong association between the first third filling fraction and the heart rate (HC r = 0.66, p less than 0.001; normal r = 0.71, p less than 0.001), reflecting its dependence on the duration of the first third of diastole.(ABSTRACT TRUNCATED AT 250 WORDS)