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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Novel selenium-doped hydroxyapatite coatings for biomedical applications
C Rodríguez-Valencia1, M López-Álvarez, B Cochón-Cores
1Department of Applied Physics, University of Vigo, 36310 Vigo, Spain.
Journal of Biomedical Materials Research. Part A
|September 13, 2012
Summary
This study introduces selenium-doped carbonated hydroxyapatite coatings for orthopedic implants. These novel coatings enhance osseointegration and exhibit significant antibacterial properties against common pathogens.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Materials Chemistry
Background:
- Metallic orthopedic implants require enhanced functionality, including improved osseointegration and antibacterial properties.
- Current hydroxyapatite (HA) coatings lack the composition of natural bone apatites, necessitating advanced formulations.
- Selenium is an essential nutrient with demonstrated antibacterial capabilities.
Purpose of the Study:
- To fabricate selenium-doped carbonated hydroxyapatite (iHA:Se) coatings using Pulsed Laser Deposition (PLD).
- To characterize the physicochemical properties of the fabricated iHA:Se coatings.
- To evaluate the biological performance, including cytotoxicity, preosteoblast proliferation, and antibacterial activity.
Main Methods:
- Pulsed Laser Deposition (PLD) for fabricating iHA:Se coatings with varying selenium content.
- Physicochemical characterization using SEM/EDS, FTIR, FT-Raman, Interferometric Profilometry, and XPS.
- Biological evaluation involving MC3T3-E1 preosteoblast cell culture and bacterial inhibition assays against P. aeruginosa and S. aureus.
Main Results:
- Successful fabrication of iHA:Se coatings with typical HA columnar growth.
- Efficient incorporation of selenium into the HA lattice, likely substituting carbonate sites (SeO(3)(2-) for CO(3)(2-)).
- No cytotoxicity observed at 0.6 at.% Se, with excellent MC3T3-E1 preosteoblast proliferation and significant inhibition of P. aeruginosa and S. aureus biofilms.
Conclusions:
- Selenium-doped carbonated hydroxyapatite coatings fabricated by PLD show promise for orthopedic applications.
- The coatings possess favorable biological properties, including enhanced osseointegration potential and potent antibacterial activity.
- This study presents a novel approach to developing advanced biomaterials for improved orthopedic implant performance.
