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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 18, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

Macular function in eyes with open-angle glaucoma evaluated by multifocal electroretinogram.

Vincenzo Parisi1, Lucia Ziccardi, Marco Centofanti

  • 1Fondazione G.B. Bietti-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.

Investigative Ophthalmology & Visual Science
|September 13, 2012
PubMed
Summary
This summary is machine-generated.

Open-angle glaucoma (OAG) patients exhibit macular dysfunction, detectable by multifocal electroretinogram (mfERG). This indicates functional impairment in the macular region

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Open-angle glaucoma (OAG) is a progressive optic neuropathy.
  • Macular function is crucial for central vision and can be affected in glaucoma.

Purpose of the Study:

  • To evaluate macular function in OAG patients using multifocal electroretinogram (mfERG).

Main Methods:

  • mfERG was performed on 24 OAG patients and 14 controls.
  • Analysis focused on N1-P1 response amplitude density (RAD) and P1 implicit time (IT) in specific retinal eccentricity rings.
  • OAG patients had controlled intraocular pressure (IOP) and specific visual field parameters.

Main Results:

  • OAG patients showed significantly reduced N1-P1 RAD and increased P1 IT in the central macular regions (R1, R2).
  • These mfERG changes correlated significantly with visual field mean deviation (MD) and corrected pattern standard deviation (CPSD).

Conclusions:

  • mfERG can detect macular dysfunction in OAG patients.
  • Findings suggest functional impairment of photoreceptors and OFF bipolar cells in the macula of glaucoma patients.