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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

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Related Experiment Video

Updated: May 18, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Inflammation in diabetic nephropathy.

Andy K H Lim1, Gregory H Tesch

  • 1Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia. andy.lim@monash.edu

Mediators of Inflammation
|September 13, 2012
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy, a major cause of kidney failure, involves inflammation. Targeting inflammation through novel experimental approaches shows promise for future diabetic nephropathy treatments.

Related Experiment Videos

Last Updated: May 18, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Diabetic nephropathy is a leading cause of end-stage kidney disease globally.
  • Current treatments for diabetic nephropathy are suboptimal, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the role of inflammation in diabetic nephropathy development and progression.
  • To update on novel experimental anti-inflammatory approaches for diabetic nephropathy.
  • To explore the link between immune deposition and diabetic nephropathy.

Main Methods:

  • Review of experimental and human diabetes studies.
  • Analysis of inflammatory cell roles (macrophages, T-lymphocytes, regulatory T cells).
  • Exploration of immune complexes and inflammatory cytokines (adipokines).
  • Examination of stress-activated protein kinases (p38 MAPK, JNK).

Main Results:

  • Inflammation, driven by infiltrating immune cells and cytokines, is central to diabetic nephropathy.
  • Immune complexes, including anti-oxidized LDL, may contribute to disease pathogenesis.
  • Stress-activated protein kinases (SAPKs) play a pathogenic role.
  • Genetic and pharmacological approaches reducing inflammation show therapeutic potential.

Conclusions:

  • Inflammation is a critical factor in diabetic nephropathy.
  • Targeting inflammatory pathways offers promising therapeutic avenues for diabetic nephropathy.
  • Further research into immune mechanisms and signaling pathways is warranted.