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Bromocriptine does not alter speed-accuracy tradeoff.

Jasper Winkel¹, Leendert van Maanen, Roger Ratcliff

¹Cognitive Science Center Amsterdam, University of Amsterdam Amsterdam, Netherlands.

Frontiers in Neuroscience

|September 13, 2012

Summary

This summary is machine-generated.

Dopamine does not affect the speed-accuracy tradeoff in perceptual decision-making. This study found bromocriptine did not alter how quickly or accurately individuals made decisions.

Keywords:

bromocriptine dopamine drift diffusion model functional magnetic resonance imaging linear ballistic accumulator model-based neuroimaging speed–accuracy tradeoff striatum

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Area of Science:

Neuroscience
Cognitive Science
Decision Science

Background:

The speed-accuracy tradeoff is a fundamental aspect of decision-making.
Dopamine is hypothesized to modulate this tradeoff, balancing fast versus accurate responses.

Purpose of the Study:

To investigate the role of dopamine in human perceptual decision-making, specifically its effect on the speed-accuracy tradeoff.
To examine whether bromocriptine, a dopamine receptor agonist, influences decision threshold and neural activity related to speed-accuracy adjustments.

Main Methods:

Utilized a cued random dot motion task where participants were instructed to prioritize speed or accuracy.
Administered bromocriptine or placebo to participants and analyzed behavioral data using drift diffusion and linear ballistic accumulator models.
Measured neural activity using fMRI, focusing on brain regions like the striatum and pre-supplementary motor area.

Main Results:

Behavioral analysis revealed significant differences in decision threshold based on speed versus accuracy instructions, but no difference between bromocriptine and placebo conditions.
Bayesian analyses supported the null hypothesis, indicating no effect of bromocriptine on decision threshold.
Neural data replicated previous findings of increased striatal and pre-supplementary motor area activation for speeded decisions, but bromocriptine did not modulate this activity.

Conclusions:

Bromocriptine does not alter the speed-accuracy tradeoff in perceptual decision-making in humans.
Dopamine modulation, at least via bromocriptine, does not appear to influence the behavioral or neural mechanisms underlying adjustments between speed and accuracy.