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Updated: May 18, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
miR-196a2 polymorphisms and susceptibility to cancer: A meta-analysis involving 24,697 subjects
Pingyu Wang1, Shuyang Xie, Aidong Cui
1School of Public Health, Shandong University, Jinan;
Abstract:
An increasing number of studies have shown that the hsa-miR-196a2 rs11614913 polymorphism occurs in different types of cancer, but the results are generally controversial and inadequate, mainly due to limited statistical power. To resolve this issue, the present meta-analysis was carried out. Databases, including PubMed and Embase, were searched using: (miR-196a2[All Fields] OR rs11614913[All Fields]) AND ('neoplasms'[MeSH Terms] OR 'neoplasms'[All Fields] OR 'cancer'[All Fields]). Crude odds ratios (ORs) with 95% confidence intervals (CIs) were summarized in forest plots and detailed in tables. A total of 20 studies, including 11,004 cases and 13,693 controls, were included in the meta-analysis. The hsa-miR-196a2 rs11614913 polymorphism was significantly associated with an increased cancer risk in all genetic models (CC vs. TT: OR=1.280, 95% CI 1.131-1.449, P<0.001; CT vs. TT: OR=1.187, 95% CI 1.079-1.306, P<0.001; CC/CT vs. TT: OR=1.216, 95% CI 1.104-1.341, P<0.001; and CC vs. CT/TT: OR=1.115, 95% CI 1.025-1.213, P=0.011). In conclusion, this meta-analysis provides compelling evidence that the hsa-miR-196a2 rs11614913 polymorphism plays a crucial role in the development of cancer. Screening of patients for the hsa-miR-196a2 rs11614913 polymorphism can prove clinically useful for the prediction and prevention of cancer.
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