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Precocious puberty in children: A review of imaging findings

Mz Faizah1, Ah Zuhanis, R Rahmah

  • 1Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.

Biomedical Imaging and Intervention Journal
|September 13, 2012
PubMed

Insights

Imaging is crucial for diagnosing precocious puberty. This review found that 84% of patients showed positive imaging findings, with hypothalamic hamartoma common in central precocious puberty and testicular adrenal rest tumour in peripheral types.

Area of Science:

  • Pediatric Endocrinology
  • Diagnostic Imaging
  • Neuroimaging

Background:

  • Precocious puberty requires identifying underlying organic causes.
  • Diagnostic imaging plays a key role in evaluating these causes.

Purpose of the Study:

  • To determine the specific imaging findings in patients diagnosed with precocious puberty.
  • To correlate imaging results with the type of precocious puberty (central vs. peripheral).

Main Methods:

  • Retrospective review of 53 patients diagnosed with precocious puberty between 2002 and 2010.
  • Analysis of diagnostic imaging (e.g., MRI, CT) performed to identify organic causes.
  • Categorization of findings based on central (gonadotrophin-dependent) or peripheral (gonadotrophin-independent) precocious puberty.

Main Results:

  • 37 patients underwent diagnostic imaging, with positive findings in 31 (84%).
  • Central precocious puberty was more common (81%), with hypothalamic hamartoma (n=10) and glioma (n=6) as frequent causes.
  • Peripheral precocious puberty causes included testicular adrenal rest tumour (n=3) and adrenal carcinoma (n=1).

Conclusions:

  • Positive imaging findings are highly prevalent in patients with precocious puberty.
  • Hypothalamic hamartoma is the leading imaging finding in central precocious puberty.
  • Testicular adrenal rest tumour is the most common imaging finding associated with peripheral precocious puberty.
Abstract

Keywords:
imagingprecocious puberty

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