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Functional screening of pharmacological chaperones via restoration of enzyme activity upon denaturation

Meera Shanmuganathan1, Philip Britz-McKibbin

  • 1Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada L8S 4M1.

Biochemistry
|September 14, 2012
PubMed

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Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...