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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

Methods for the drug effectiveness review project.

Marian S McDonagh1, Daniel E Jonas, Gerald Gartlehner

  • 1Department of Medical Informatics and Clinical Epidemiology and Evidence-based Practice Center, School of Medicine, Oregon Health & Science University, Portland, OR, USA. mcdonagh@ohsu.edu

BMC Medical Research Methodology
|September 14, 2012
PubMed
Summary
This summary is machine-generated.

The Drug Effectiveness Review Project provides evidence-based drug reviews for Medicaid programs. These comparative effectiveness reviews inform policy decisions, ensuring cost-effective pharmaceutical access for recipients.

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Area of Science:

  • Health Services Research
  • Pharmaceutical Policy
  • Evidence-Based Medicine

Background:

  • Rising pharmaceutical costs strained state Medicaid budgets starting in 2003.
  • A collaborative effort was needed to ensure cost-effective drug access for Medicaid recipients.

Purpose of the Study:

  • To establish a project for high-quality comparative effectiveness reviews of pharmaceuticals.
  • To inform evidence-based drug selection for state Medicaid programs.
  • To enhance the impact of systematic reviews on policy decisions.

Main Methods:

  • Systematic reviews conducted by Evidence-based Practice Centers (EPCs).
  • Collaboration between state Medicaid agencies, Center for Evidence-based Policy (CEbP), and EPCs.
  • Development and application of rigorous methods for review conduct and stakeholder engagement.

Main Results:

  • The project successfully produces high-standard comparative effectiveness reviews.
  • Direct communication with policymakers ensures reports influence decision-making.
  • Innovative methods for stakeholder involvement enhance review relevance.

Conclusions:

  • The Drug Effectiveness Review Project effectively informs evidence-based drug decisions for Medicaid.
  • The project's methods and stakeholder engagement are crucial for policy impact.
  • Continued development of review methodologies ensures ongoing relevance and utility.