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Updated: May 18, 2026

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

Nutritional intervention for amyotrophic lateral sclerosis.

I Morassutti¹, M Giometto, C Baruffi

¹Metabolic and Nutrition Unit, Local Health Unit (ULSS 9), Treviso, Italy. ildamaria.morassutti@gmail.com

Minerva Gastroenterologica E Dietologica

|September 14, 2012

Summary

This summary is machine-generated.

Early nutritional intervention in amyotrophic lateral sclerosis (ALS) patients helps maintain nutritional status and reduces mortality. Standard enteral nutrition formulas are effective when artificial nutrition is needed.

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Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

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A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)

Published on: February 21, 2011

Area of Science:

Neurology
Clinical Nutrition
Biostatistics

Background:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
Maintaining nutritional status is crucial for ALS patient outcomes.
Early intervention may mitigate disease progression and improve quality of life.

Purpose of the Study:

To evaluate the impact of early and systematic nutritional intervention on ALS patients.
To assess the ability to maintain good nutritional status for longer periods.
To compare clinical outcomes between a protocol group and a control group.

Main Methods:

A study involving 33 ALS patients, divided into a Protocol Group (12 patients) and a Control Group (21 patients).
The Protocol Group received a precise nutritional intervention, while the Control Group was monitored before protocol implementation.
Data collected included Body Mass Index (BMI), percentage of weight loss, need for enteral nutrition, and mortality rates.

Main Results:

The Protocol Group exhibited significantly less weight loss at 6 and 12 months compared to the Control Group (P=0.002 and P=0.03, respectively).
Fewer patients in the Protocol Group required enteral nutrition at follow-up visits (25% vs. 60% at first visit).
The Protocol Group had a lower one-year mortality rate (17%) compared to the Control Group (33%).

Conclusions:

Early and specific nutritional intervention in ALS patients, before significant weight loss, effectively preserves nutritional status.
Standard enteral nutrition diets are adequate for achieving positive clinical results when artificial nutrition is necessary.
Systematic nutritional management can improve clinical conditions and survival in ALS patients.