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Updated: May 18, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Effects of sterilization and storage on the properties of ALP-grafted biomaterials for prosthetic and bone tissue
S Ferraris1, G Pan, C Cassinelli
1Politecnico di Torino, Department of Applied Science and Technology, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy. sara.ferraris@polito.it
Abstract:
Grafting of the biomaterial surfaces with biomolecules is nowadays a challenging research field for prosthetic and bone tissue engineering applications. On the other hand, very few research works investigate the effect of the sterilization processes on the properties of functionalized biomaterials. In this study, the effects of different sterilization techniques (e.g. gamma and electron beam irradiation, ethylene oxide) on the enzymatic activity of bioactive glasses and Ti6Al4V grafted with alkaline phosphatase (ALP) have been analyzed. Sterility maintenance and in vitro bioactivity of the sterilized surfaces have also been investigated. Finally the effect of packaging and storage conditions has been considered.
