Prophylactic antibiotic administration for prevention of surgical site infection in urological laparoscopic surgeries

The purpose of this study is to investigate the occurrence of surgical site infection (SSI) in our cases after laparoscopic surgery with prophylactic antibiotics administration (PAA) of 1-2 days or 3 days duration.

Two hundred and nine patients were enrolled in this study. SSIs were categorized as urinary tract and/or wound infection. Laboratory data relating to infection such as serum white blood cell (WBC) and C-reactive protein (CRP) were investigated after surgeries and compared to the data before surgeries. Data were collected and analyzed retrospectively.

There were 4 SSI patients in total. SSI was 4/125 (3.2 %) cases of PAA of 1-2 days (shorter) duration patients and there was 0/84 (0 %) of PAA of 3 days (longer) duration. Longer group showed the tendency of lower SSI ratio even though the difference did not reach statistically significant (p=0.0978) because of small number of SSI cases and ratios. Change of serum WBC at 4th day from pre-surgery was significantly suppressed in longer group than shorter group.

Our data showed 3-days of PAA might be better to be selected according to the cases especially such as, for instance, immune-compromised hosts. Future prospective study with more number of patients may be necessary for further evaluation.