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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Updated: May 18, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Understanding disparities in leukemia: a national study.

M I Patel1, Y Ma, B S Mitchell

  • 1Department of Medicine, Division of Hematology/Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305, USA. tarheelmanali@gmail.com

Cancer Causes & Control : CCC
|September 14, 2012
PubMed
Summary
This summary is machine-generated.

Blacks and Hispanics experience higher mortality rates from acute leukemia compared to non-Hispanic whites. These disparities persist even after accounting for patient and genetic factors, indicating a need for further research into cancer outcome drivers.

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Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Area of Science:

  • Hematologic malignancies research
  • Cancer disparities
  • Population-based studies

Background:

  • Solid tumor disparities are well-documented.
  • Hematologic malignancy disparities remain underexplored at population levels.

Purpose of the Study:

  • To investigate the association between race/ethnicity and mortality in acute leukemia patients.
  • To identify survival differences in acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) based on race/ethnicity.

Main Methods:

  • Utilized Surveillance Epidemiology and End Results (SEER) database (1999-2008) for 39,002 acute leukemia patients.
  • Employed Kaplan-Meier curves for survival probability analysis by race/ethnicity.
  • Conducted multivariable Cox proportional hazard models, adjusting for age, gender, diagnosis year, and genetic factors.

Main Results:

  • Blacks (HR 1.17) and Hispanics (HR 1.13) showed significantly higher acute leukemia mortality than non-Hispanic whites.
  • Disparities were more pronounced in acute lymphoblastic leukemia (ALL) than acute myelogenous leukemia (AML) for both Black and Hispanic populations.
  • Adjustments for individual and genetic factors did not account for the observed mortality disparities.

Conclusions:

  • Black and Hispanic individuals face poorer survival outcomes in acute leukemia compared to other racial groups.
  • Further research is essential to elucidate the underlying causes of these cancer outcome disparities.
  • Addressing these disparities is crucial for improving cancer care equity.