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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Interventions for recurrent corneal erosions.

Stephanie L Watson1, Ming-Han H Lee, Nigel H Barker

  • 1Save Sight Institute, Sydney, Australia. stephanie.watson@sydney.edu.au.

The Cochrane Database of Systematic Reviews
|September 14, 2012
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Summary

Current treatments for recurrent corneal erosion lack consensus. More high-quality trials are needed to establish effective prophylactic and treatment regimens for this common, disabling eye condition.

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Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
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Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

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Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Ocular Surface Disease

Background:

  • Recurrent corneal erosion (RCE) is a frequent cause of debilitating eye symptoms and increases infection risk.
  • It often follows corneal trauma, and preventive measures are not well-established.
  • While simple medical therapy can resolve episodes, some patients experience persistent symptoms or recurring erosions.

Purpose of the Study:

  • To evaluate the efficacy and safety of various prophylactic and treatment strategies for recurrent corneal erosion.

Main Methods:

  • Conducted a systematic search of multiple electronic databases (CENTRAL, MEDLINE, EMBASE, LILACS, mRCT, ClinicalTrials.gov, ICTRP) up to June 2012.
  • Included randomized and quasi-randomized controlled trials comparing different regimens or placebo for RCE.
  • Data extraction and quality assessment were performed independently by two authors.

Main Results:

  • Seven randomized and one quasi-randomized trial were included; trials were heterogeneous and of poor quality with incomplete safety data.
  • For treatment, oral tetracycline, topical prednisolone, or excimer laser ablation showed potential benefits in healing and symptom reduction.
  • Prophylactic treatments like hypertonic saline, tetracycline, or lubricating ointments showed no significant difference in preventing RCE episodes or symptoms in limited studies.

Conclusions:

  • High-quality, masked, randomized controlled trials with standardized methods are essential to validate new and existing RCE treatments.
  • International consensus is required to guide research toward evaluating the most effective RCE interventions.