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Updated: May 18, 2026
09:54
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
Normal circulating PTH in Saudi healthy individuals with hypovitaminosis D
Y Al-Saleh1, N M Al-Daghri, K M Alkharfy
1Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|September 14, 2012
Summary
Vitamin D deficiency is common in Saudi Arabia, even with ample sunlight. This study found that active vitamin D [1,25(OH)2D] levels were normal in deficient individuals, suggesting new clinical cutoffs are needed.
Area of Science:
- Endocrinology
- Nutritional Science
- Public Health
Background:
- Vitamin D deficiency is prevalent in the Middle East, despite abundant sunlight.
- Limited data exists on active vitamin D [1,25(OH)2D] levels and cardiometabolic associations in Arab populations.
Purpose of the Study:
- To investigate the levels of active vitamin D [1,25(OH)2D] and their relationship with cardiometabolic parameters in vitamin D-deficient Saudis.
- To assess associations between 1,25(OH)2D, parathyroid hormone (PTH), and cardiometabolic markers.
Main Methods:
- Cross-sectional study of 76 Saudis (children and adults) with low serum 25-hydroxyvitamin D [25(OH)D].
- Measurements included anthropometrics, glucose, lipid profile, calcium, albumin, serum 25(OH)D, 1,25(OH)2D, and intact PTH using ELISAs.
Main Results:
- Serum calcium, intact PTH, and 1,25(OH)2D were within normal ranges for all participants.
- 1,25(OH)2D showed no association with intact PTH.
- Circulating 1,25(OH)2D inversely correlated with systolic blood pressure and waist circumference.
Conclusions:
- Vitamin D deficient Saudi children and adults maintained normal active vitamin D, calcium, and PTH levels.
- The study suggests establishing local clinical cutoffs for vitamin D to identify individuals at risk for secondary hyperparathyroidism and bone diseases.
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