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In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
Published on: July 23, 2010
Host-cell factors involved in papillomavirus entry
Luise Florin1, Martin Sapp, Gilles A Spoden
1Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany. lflorin@uni-mainz.de
Medical Microbiology and Immunology
|September 14, 2012
Summary
Human papillomaviruses (HPVs) use a multistep process to infect cells, engaging numerous host proteins for entry. This review details the viral entry pathway and cellular factors involved.
Area of Science:
- Virology
- Cell Biology
- Infectious Diseases
Background:
- Papillomaviruses cause warts and cancers by infecting skin and mucosal tissues.
- Viral entry into host cells is a complex, multistep process essential for infection.
Purpose of the Study:
- To review the current understanding of the papillomavirus entry pathway.
- To highlight the roles of cellular proteins in papillomavirus infection.
Main Methods:
- Literature review of papillomavirus entry mechanisms.
- Analysis of host-pathogen interactions during viral infection.
Main Results:
- Papillomavirus entry involves sequential engagement of host proteins, starting with L1 major capsid protein binding.
- The process includes capsid structural changes, receptor engagement, endocytosis, and post-entry events like nuclear transport.
Conclusions:
- Understanding the papillomavirus entry pathway is crucial for developing antiviral strategies.
- Cellular proteins play critical roles throughout the viral lifecycle, from entry to nuclear accumulation.
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