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Related Experiment Video

Updated: May 18, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Endothelial dysfunction and hypertension in aging.

Yukihito Higashi¹, Yasuki Kihara, Kensuke Noma

¹Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima, Japan. yhigashi@hiroshima-u.ac.jp

Hypertension Research : Official Journal of the Japanese Society of Hypertension

|September 14, 2012

Summary

This summary is machine-generated.

Aging exacerbates endothelial dysfunction, a key factor in hypertension development. This review explores how impaired nitric oxide (NO) bioavailability and increased oxidative stress contribute to age-related hypertension and cardiovascular risks.

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Published on: October 22, 2014

Area of Science:

Cardiovascular Science
Gerontology
Vascular Biology

Background:

Hypertension prevalence significantly increases with age, posing risks for cardiovascular and cerebrovascular complications.
Both aging and hypertension independently impair endothelial function, a critical regulator of vascular tone.
Endothelial dysfunction, characterized by reduced nitric oxide (NO) bioavailability, contributes to elevated blood pressure.

Purpose of the Study:

To review recent findings on the interactions between endothelial function, oxidative stress, and hypertension in the aging process.
To elucidate the mechanisms linking aging-induced endothelial dysfunction to increased hypertension risk.
To highlight the role of oxidative stress and endothelial cell senescence in age-related vascular changes.

Main Methods:

Literature review focusing on recent research in aging, hypertension, endothelial function, and oxidative stress.
Analysis of studies investigating the role of nitric oxide (NO) and reactive oxygen species (ROS) in endothelial dysfunction.
Examination of evidence linking endothelial cell senescence to age-related vascular pathology.

Main Results:

Aging is associated with progressive endothelial dysfunction, partly mediated by increased oxidative stress.
An imbalance between reduced NO production and increased superoxide generation promotes endothelial dysfunction.
Endothelial cell senescence emerges as a significant factor in age-related endothelial dysfunction and hypertension.

Conclusions:

Age-related endothelial dysfunction, driven by oxidative stress and cellular senescence, is a primary mechanism underlying increased hypertension prevalence in the elderly.
Maintaining endothelial function and reducing oxidative stress are crucial for mitigating cardiovascular risks associated with aging and hypertension.
Further research into the interplay of aging, oxidative stress, and vascular health is warranted to develop effective interventions.