Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of DNA methylation and chromatin accessibility on regulation of gene expression during <i>Trichomonas vaginalis-</i>host cell interaction.

mBio·2025
Same author

Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.

BMC infectious diseases·2025
Same author

Targeting histone acetylation to overcome drug resistance in the parasite <i>Trichomonas vaginalis</i>.

bioRxiv : the preprint server for biology·2025
Same author

miR-203 secreted in extracellular vesicles mediates the communication between neural crest and placode cells required for trigeminal ganglia formation.

PLoS biology·2024
Same author

miR-137 confers robustness to the territorial restriction of the neural plate border.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: May 18, 2026

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
08:37

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

Epigenetic landscape and miRNA involvement during neural crest development.

Pablo H Strobl-Mazzulla1, Melisa Marini, Ailín Buzzi

  • 1Laboratory of Developmental Biology, Instituto de Investigaciones Biotecnológicas- Instituto Tecnológico de Chascomús, Chascomús, Argentina. strobl@intech.gov.ar

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|September 14, 2012
PubMed
Summary

Neural crest (NC) development relies on gene regulatory networks, but epigenetic factors and microRNAs (miRNAs) are also crucial. This review highlights recent findings on chromatin and miRNA regulation in vertebrate NC cell development.

More Related Videos

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

Related Experiment Videos

Last Updated: May 18, 2026

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
08:37

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Neural crest (NC) cells are multipotent and migratory, originating from the dorsal neural fold in vertebrate embryos.
  • NC cells differentiate into diverse cell types, forming craniofacial structures, neurons, glia, and endocrine cells.
  • While gene regulatory networks are well-studied, epigenetic and posttranscriptional regulations are increasingly recognized for their roles in NC development.

Purpose of the Study:

  • To review recent advancements in understanding epigenetic and posttranscriptional regulation of vertebrate neural crest cell development.
  • To focus on chromatin-dependent mechanisms and microRNA (miRNA) regulation in NC development.

Main Methods:

  • Literature review of recent findings on neural crest cell development.
  • Focus on chromatin modifications and miRNA involvement.

Main Results:

  • Recent studies reveal significant roles for chromatin-dependent mechanisms in regulating NC cell development.
  • MicroRNAs (miRNAs) are identified as key posttranscriptional regulators influencing NC cell fate and migration.
  • Integration of gene regulatory networks with epigenetic and miRNA data provides a more comprehensive view of NC development.

Conclusions:

  • Epigenetic mechanisms, particularly chromatin regulation, are essential for orchestrating neural crest cell development.
  • MicroRNAs play critical roles in posttranscriptional control, fine-tuning gene expression during NC cell differentiation and migration.
  • A holistic understanding of NC development requires integrating genetic, epigenetic, and posttranscriptional regulatory layers.