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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 18, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Age-associated inflammation inhibits epidermal stem cell function.

Jason Doles1, Mekayla Storer, Luca Cozzuto

  • 1Centre for Genomic Regulation, Barcelona 08003, Spain.

Genes & Development
|September 14, 2012
PubMed
Summary
This summary is machine-generated.

Aging skin stem cells show increased numbers but decreased function due to an imbalance in epidermal Jak-Stat signaling. This age-associated decline impacts stem cell homeostasis and may be a tumor-suppressive mechanism.

Related Experiment Videos

Last Updated: May 18, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Area of Science:

  • Stem cell biology
  • Dermatology
  • Aging research

Background:

  • Stem cell homeostasis is crucial for organismal aging, but underlying mechanisms are unclear.
  • Skin aging involves complex changes in stem cell populations and function.

Purpose of the Study:

  • To investigate alterations in hair follicle stem cells during skin aging.
  • To identify molecular mechanisms driving age-associated stem cell dysfunction.

Main Methods:

  • High-throughput RNA sequencing of aging stem cells.
  • Cytokine array analysis.
  • Functional assays to assess stem cell behavior and stress tolerance.

Main Results:

  • Aging hair follicle stem cells exhibited increased numbers, reduced function, and impaired stress tolerance.
  • An age-associated imbalance in epidermal Janus kinase-Signal Transducer and Activator of Transcription (Jak-Stat) signaling was identified.
  • This signaling imbalance was found to inhibit stem cell function.

Conclusions:

  • The aging epidermis contributes to the disruption of cytokine and stem cell homeostasis.
  • Stem cell decline during aging may represent a broader tumor-suppressive mechanism.