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Value of C-reactive protein in predicting left ventricular remodelling in patients with a first ST-segment elevation

Iwona Swiatkiewicz1, Marek Kozinski, Przemyslaw Magielski

  • 1Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. i.swiat@wp.pl

Mediators of Inflammation
|September 14, 2012
PubMed

Insights

C-reactive protein (CRP) measured 24 hours after a heart attack shows a modest ability to predict left ventricular remodelling (LVR). Higher CRP levels correlate with increased LVR risk in STEMI patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Left ventricular remodelling (LVR) is a significant complication following myocardial infarction.
  • Predicting LVR is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To evaluate the predictive value of C-reactive protein (CRP) for LVR after a first ST-segment elevation myocardial infarction (STEMI).

Main Methods:

  • Plasma CRP concentrations were measured in 198 patients during hospitalization for a first STEMI.
  • LVR was assessed at 6 months post-infarction.
  • Multivariate analysis and ROC analysis were used to determine CRP's predictive value.

Main Results:

  • LVR was observed in 27.8% of patients at 6 months.
  • CRP concentrations increased within 24 hours, particularly in the LVR group.
  • Higher CRP quartiles at 24 hours were associated with increased LVR prevalence (OR 3.48).
  • Independent predictors of LVR included CRP at 24h, B-type natriuretic peptide, BMI, and left ventricular end-diastolic volume.
  • CRP showed limited discriminative value for LVR prediction (AUC 0.61).

Conclusions:

  • CRP measurement at 24 hours post-admission has a significant yet modest value in predicting LVR after a first STEMI.
  • While a useful indicator, CRP should be considered alongside other clinical and biochemical markers for comprehensive LVR risk assessment.
Abstract

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