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Related Experiment Video

Updated: May 18, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Polymyalgia rheumatica in a married couple.

Christoph Alexander Rüst¹, Beat Knechtle, Thomas Rosemann

¹Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland;

International Journal of General Medicine

|September 14, 2012

Summary

This case study presents a married couple diagnosed with polymyalgia rheumatica (PMR) consecutively. Their response to steroid and methotrexate treatment suggests potential shared environmental or infectious triggers, challenging genetic hypotheses.

Keywords:

C-reactive protein erythrocyte sedimentation rate husband polymyalgia rheumatica wife

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Last Updated: May 18, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

Rheumatology
Epidemiology

Background:

Polymyalgia rheumatica (PMR) is an inflammatory condition primarily affecting individuals over 50.
The etiology of PMR remains largely unknown, with genetic and infectious factors previously hypothesized.

Observation:

A married couple presented with consecutive diagnoses of PMR.
Both individuals experienced symptom recurrence upon steroid dose reduction.
Treatment involved glucocorticoids and methotrexate, with the latter added to reduce cumulative steroid exposure.

Findings:

The consecutive occurrence of PMR in a married couple is rare, with only six previous cases reported in the literature.
The observed pattern challenges the prevailing hypotheses of solely genetic predisposition or infectious agents as primary causes.
Shared environmental factors may play a role in the development of PMR within couples.

Implications:

This case highlights the need to explore non-genetic and non-infectious etiological factors in PMR.
Further research into shared environmental exposures could provide new insights into PMR pathogenesis.
Understanding familial clustering may inform future diagnostic and therapeutic strategies for PMR.