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Pathogenicity of Acanthamoeba and a Corynebacterium in the rat cornea
P R Badenoch1, A M Johnson, P E Christy
1Department of Ophthalmology, Flinders Medical Centre, Bedford Park, South Australia.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1990
Abstract:
Acanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition.