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Related Experiment Video

Updated: May 18, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Neonatal lupus erythematosus.

Kam Lun Hon¹, Alexander K C Leung

¹Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Sciences Building, Shatin, Hong Kong.

Autoimmune Diseases

|September 14, 2012

Summary

This summary is machine-generated.

Neonatal lupus erythematosus (NLE) is a rare condition in newborns linked to maternal autoantibodies. Early detection and specialized care are crucial for managing NLE and preventing serious complications.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

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Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Immunology
Pediatrics
Rheumatology

Background:

Neonatal lupus erythematosus (NLE) presents with diverse symptoms in infants.
It is associated with maternal autoantibodies, specifically anti-Ro/SSA and anti-La/SSB.
While often self-limiting, NLE can lead to severe outcomes.

Purpose of the Study:

To review the pathophysiology of NLE.
To outline the clinical features and management strategies for infants with NLE.
To discuss recurrence risks and monitoring in subsequent pregnancies.

Main Methods:

Literature review on NLE pathophysiology, clinical presentation, and management.
Analysis of recurrence data for pregnancies with maternal autoantibodies and infant congenital heart block.

Main Results:

NLE involves a spectrum of abnormalities including skin, cardiac, and systemic issues.
Management typically requires tertiary care center involvement and a multidisciplinary team.
Subsequent pregnancy recurrence risk is 17-25% for mothers with anti-Ro/SSA/anti-La/SSB antibodies and infants with congenital heart block.

Conclusions:

Neonates with NLE require specialized medical attention.
Close monitoring of future pregnancies is essential due to significant recurrence risk.
Serial ultrasonography and echocardiography are vital for managing at-risk pregnancies.