Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 18, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Quantitative trait loci affecting liver fat content in mice.

Olga Minkina1, James M Cheverud, Gloria Fawcett

  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

G3 (Bethesda, Md.)
|September 14, 2012
PubMed
Summary

Genetic factors influence liver fat accumulation, a key feature of nonalcoholic fatty liver disease. This study identified three genetic loci contributing to liver fat content in mice, offering insights into metabolic syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size.

eLife·2026
Same author

LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD.

Journal of lipid research·2026
Same author

Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease.

iScience·2025
Same author

Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease.

JACC. Basic to translational science·2025
Same author

Easier said than done: unexpected hurdles to preparing ∼1,000 cranial CT scans for data collection from an online digital repository.

PeerJ·2025

Area of Science:

  • Genetics
  • Hepatology
  • Metabolic Syndrome

Background:

  • Nonalcoholic fatty liver disease (NAFLD) involves excess liver fat and is linked to metabolic syndrome.
  • NAFLD can progress to severe liver damage like fibrosis and cirrhosis.
  • Diet and activity changes drive metabolic syndrome, but genetic variations also impact individual responses to obesity.

Purpose of the Study:

  • To investigate the genetic basis of variation in liver fat content.
  • To identify genetic loci influencing liver fat accumulation in response to dietary fat.

Main Methods:

  • Quantitative magnetic resonance imaging was used to measure liver fat proportion.
  • 478 mice from 16 recombinant inbred strains were fed high-fat or low-fat diets.
  • Analysis of variance and quantitative trait loci (QTL) mapping were employed.
Keywords:
LG/JNAFLDQTLSM/Jmousenonalcoholic fatty liver disease

More Related Videos

Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

Related Experiment Videos

Last Updated: May 18, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

Main Results:

  • A significant genetic basis for variation in liver fat content was confirmed.
  • Sex and diet significantly affected liver fat content.
  • Three quantitative trait loci (QTL) contributing to liver fat content were identified.

Conclusions:

  • Genetic variation plays a role in determining liver fat content in response to dietary fat.
  • The identified QTL provide targets for further research into the genetic underpinnings of NAFLD and metabolic syndrome.
  • Understanding these genetic factors is crucial for developing targeted interventions.