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Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Oral Drug Delivery Systems: Introduction

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

Modified-Release Drug Delivery Systems: Site-Targeted

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Related Experiment Video

Updated: May 18, 2026

Nanosponge Tunability in Size and Crosslinking Density

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Current trends in microsponge drug delivery system.

H V Gangadharappa¹, N Vishal Gupta, Sarat Chandra Prasad M

¹Department of pharmaceutics, JSS College of Pharmacy, JSS University, Mysore-15, India. malisettysarat@yahoo.com

Current Drug Delivery

|September 15, 2012

Summary

Microsponge technology offers an advanced topical delivery system. These microscopic spheres absorb skin oil and release active ingredients effectively, overcoming limitations of conventional preparations.

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Published on: September 2, 2009

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Nanosponge Tunability in Size and Crosslinking Density

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Published on: August 4, 2017

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Published on: September 2, 2009

Area of Science:

Pharmaceutical Sciences
Dermatology
Materials Science

Background:

Conventional topical preparations often suffer from drawbacks like irritancy, odor, greasiness, and poor patient compliance.
Many topical formulations fail to deliver sufficient amounts of active ingredients to the target site.
Microsponge technology presents a novel solution to these challenges in topical drug delivery.

Purpose of the Study:

To explore the potential of microsponge formulations as an improved topical delivery system.
To highlight the advantages of microsponge technology over traditional topical preparations.
To discuss the application of microsponges and nanosponges in skincare and drug delivery.

Main Methods:

Characterization of microsponge particle size (10-25 microns).
Evaluation of ingredient entrapment and controlled release capabilities.
Assessment of microsponge properties including non-allergenic, non-toxic, non-irritant, and non-mutagenic characteristics.

Main Results:

Microsponges effectively absorb skin secretions, reducing oiliness.
They allow for the entrapment of various ingredients within a single system.
Drug release can be controlled by external stimuli such as pH, temperature, and rubbing.

Conclusions:

Microsponge technology offers significant advantages for topical applications, including enhanced efficacy and patient compliance.
These systems are versatile and can be incorporated into various products like sunscreens, creams, and ointments.
Recent advancements include nanosponges utilizing cyclodextrins for improved solubility of poorly water-soluble drugs in topical formulations.