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Updated: May 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and Preliminary In-Vitro Cytotoxic Activity of Various Novel 4-(N-Substituted Benzothiazolyl)
Nisharth Dave1, P Gopkumar, Badiger M Arvind
1Department of Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat 394110, India. gopnitk@gmail.com.
Abstract:
A variety of 4-(N-substituted benzothiazolyl) amino-7-methoxy-6-(3-morpholinopropoxy) quinazoline were synthesized by using various N-substituted 2-amino benzothiazole, and substituted quinazoline. The structures of these compounds were confirmed by IR, Mass and 1HNMR spectral analysis. Newly synthesized compounds were tested for their In-Vitro Cytotoxic Activity using MTT assay. Results of the study indicated novel series of N-substituted (1, 3-benzothiazole)-7-methoxy-6-(3-morpholinopropoxy) quinazoline-4-yl-amine derivatives are potential class of anticancer agents.
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