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A protocol for a systematic review for perioperative pregabalin use
Naveen Eipe1, John Penning, Mohammed Ansari
1The Ottawa Hospital (TOH), 1053 Carling Avenue, Suite B310, Ottawa, Ontario K1Y 4E9, Canada. neipe@toh.on.ca
Systematic Reviews
|September 15, 2012
Summary
This systematic review will examine pregabalin for perioperative pain, updating evidence on its effectiveness and side effects. It aims to identify patient and surgical factors influencing pregabalin
Area of Science:
- Anesthesiology and Pain Management
- Pharmacology
- Evidence-Based Medicine
Background:
- Perioperative pain management has evolved with new drugs and mechanisms.
- Pregabalin, an anti-epileptic, is studied for acute pain, with reviews suggesting reduced pain and analgesic needs but potential side effects.
- Existing reviews lack detailed analysis of patient and surgical factors influencing pregabalin's benefit-harm ratio.
Purpose of the Study:
- To update systematic reviews on perioperative pregabalin use.
- To investigate heterogeneity in findings across different surgical pain models.
- To identify clinical characteristics maximizing the benefit-harm ratio for surgical patients.
Main Methods:
- Comprehensive search of databases for adult perioperative pregabalin trials, supplemented by reference list scanning.
- Inclusion of studies regardless of language, country, or year of publication.
- Focus on pain, opioid use, enhanced recovery, drug-related harms, and identification of beneficial/adverse effect predictors.
Main Results:
- Systematic review and meta-analysis (if feasible) of clinical trial data.
- Assessment of publication bias and risk of bias using Cochrane tools.
- Grading of evidence strength for key outcomes.
Conclusions:
- Explore findings from perioperative pregabalin trials for acute pain.
- Comment on implications and provide guidance for appropriate pregabalin use.
- Bridge the gap between clinical practice and evidence to inform future guidelines.
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