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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...

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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

[Neurological complications in patients receiving solid organ transplants].

J A Fernández-Ramos¹, E López-Laso, M D Ordóñez-Díaz

¹Unidad de Neurología Pediátrica, Hospital Universitario Reina Sofía, Córdoba, España. jafdezramos@gmail.com

Anales De Pediatria (Barcelona, Spain : 2003)

|September 15, 2012

Summary

Neurological complications are common in pediatric solid organ transplant recipients, with seizures and encephalopathy being most frequent. Immunosuppressant neurotoxicity and hypoxic-ischemic encephalopathy are primary causes, impacting patient outcomes.

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Last Updated: May 18, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

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Published on: November 7, 2020

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

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Published on: November 17, 2014

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

Area of Science:

Pediatric transplantation
Neurology
Immunosuppression

Context:

Neurological complications (NC) significantly impact morbidity and mortality in pediatric solid organ transplant (SOT) recipients.
Understanding the spectrum and causes of NC is crucial for improving patient care and outcomes.

Purpose:

To describe the hospital's experience with neurological complications in pediatric patients undergoing heart, lung, and liver transplants.
To identify the incidence, clinical manifestations, etiologies, and outcomes of NC in this population.

Summary:

A retrospective study of 140 pediatric SOT recipients (2000-2011) found 16.4% experienced NC.
Acute symptomatic seizures and acute encephalopathy were the most common NC, with immunosuppressive drug neurotoxicity and hypoxic-ischemic encephalopathy as leading causes.
Outcomes varied, with favorable prognosis for posterior reversible encephalopathy syndrome but mortality associated with hypoxic-ischemic encephalopathy.

Impact:

Highlights the prevalence and common causes of neurological complications in pediatric solid organ transplantation.
Informs clinical management strategies for preventing and treating NC in transplant recipients.
Emphasizes the distinct etiologies and prognoses associated with different causes of NC.