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[Neurological complications in patients receiving solid organ transplants]
J A Fernández-Ramos1, E López-Laso, M D Ordóñez-Díaz
1Unidad de Neurología Pediátrica, Hospital Universitario Reina Sofía, Córdoba, España. jafdezramos@gmail.com
Anales De Pediatria (Barcelona, Spain : 2003)
|September 15, 2012
Summary
Neurological complications are common in pediatric solid organ transplant recipients, with seizures and encephalopathy being most frequent. Immunosuppressant neurotoxicity and hypoxic-ischemic encephalopathy are primary causes, impacting patient outcomes.
Area of Science:
- Pediatric transplantation
- Neurology
- Immunosuppression
Context:
- Neurological complications (NC) significantly impact morbidity and mortality in pediatric solid organ transplant (SOT) recipients.
- Understanding the spectrum and causes of NC is crucial for improving patient care and outcomes.
Purpose:
- To describe the hospital's experience with neurological complications in pediatric patients undergoing heart, lung, and liver transplants.
- To identify the incidence, clinical manifestations, etiologies, and outcomes of NC in this population.
Summary:
- A retrospective study of 140 pediatric SOT recipients (2000-2011) found 16.4% experienced NC.
- Acute symptomatic seizures and acute encephalopathy were the most common NC, with immunosuppressive drug neurotoxicity and hypoxic-ischemic encephalopathy as leading causes.
- Outcomes varied, with favorable prognosis for posterior reversible encephalopathy syndrome but mortality associated with hypoxic-ischemic encephalopathy.
Impact:
- Highlights the prevalence and common causes of neurological complications in pediatric solid organ transplantation.
- Informs clinical management strategies for preventing and treating NC in transplant recipients.
- Emphasizes the distinct etiologies and prognoses associated with different causes of NC.
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