Related Experiment Video

Updated: May 18, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

Colonic conduit for esophageal replacement: long-term endoscopic and histopathologic changes in colonic mucosa

Hossam Elshafei1, Ehab Elshafei, Mohamed ElDebeiky

  • 1Pediatric Surgery Unit and Pathology Department, Ain Shams University Hospital, Cairo, Egypt. hossamshafei@yahoo.com

Journal of Pediatric Surgery
|September 15, 2012
PubMed

Insights

The colon is a durable esophageal substitute in children, showing minimal long-term histopathologic changes despite gastric acid exposure. Antireflux procedures can further protect this colonic conduit.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Surgical Pathology

Background:

  • The colon serves as a durable and well-accepted esophageal substitute.
  • Gastric acid exposure can induce chronic inflammation in colonic conduits used for esophageal replacement.

Purpose of the Study:

  • To evaluate the long-term histopathologic changes in colonic conduits used for esophageal replacement in children.
  • To assess the functional integrity of the colonic mucosa following esophageal substitution.

Main Methods:

  • Upper gastrointestinal endoscopy was performed on 30 children 2-12 years post-esophageal replacement.
  • Punch biopsies were obtained from the upper and lower junctions of the colonic conduit.
  • Biopsies underwent histopathologic examination to assess mucosal changes.

Main Results:

  • Most colonic conduits (83.3%) showed normal gross endoscopic appearance.
  • Mild chronic nonspecific inflammation (23.4%) and mildly active inflammation (3.3%) were the main pathological findings.
  • Minimal changes were observed, with most cases showing normal or near-normal histopathology.

Conclusions:

  • Colonic mucosa demonstrates resilience to gastric acid reflux, maintaining function as an esophageal substitute long-term.
  • No significant pathological changes were found that would compromise the conduit's function.
  • Antireflux procedures may offer additional protection for colonic conduits.
Abstract

More Related Videos

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD: