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Polyurethane arterial prosthesis: experimental evaluation.

C Martin-Mondiere1, P David, D Loisance

  • 1Centre de Recherches Chirurgicales, CNRS, UA 591, Université Paris XII, Créteil, France.

Annals of Vascular Surgery
|January 1, 1990
PubMed
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This study evaluated microporous polyurethanes for vascular prostheses. Pretreatment with laminin, fibronectin, and astrocyte cells improved hemocompatibility, though the raw material showed limitations.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Cell Biology

Background:

  • Microporous polyurethanes are investigated as potential materials for arterial prostheses.
  • Assessing the hemocompatibility and biological interactions of biomaterials is crucial for clinical success.

Purpose of the Study:

  • To evaluate the in vitro and in vivo performance of two types of microporous polyurethanes.
  • To determine the impact of various pretreatments on the hemocompatibility and cellular interactions of polyurethane materials.

Main Methods:

  • Polyurethane disks were seeded with bovine aortic endothelial cells and human greater omentum cells.
  • Cell proliferation was assessed daily using trypan blue staining.
  • In vivo studies involved implanting polyurethane arterial prostheses in carotid arteries of animals.

Related Experiment Videos

  • Cell identification utilized class I MHC antigen characterization and factor VIII staining.

    • Main Results:

    • Pretreatments including poly L-lysine, laminin, fibronectin, and astrocyte cell seeding demonstrated benefits in vitro.
    • The raw polyurethane material exhibited unsatisfactory hemocompatibility in both in vitro and in vivo evaluations.
    • Pretreatment with laminin, fibronectin, and astrocyte cells enhanced the biological characteristics of the polyurethane.

    Conclusions:

    • While basic polyurethane material shows limitations in hemocompatibility for vascular applications, specific biological pretreatments can significantly improve its performance.
    • Further research into optimized surface modifications is warranted for developing effective polyurethane-based arterial prostheses.