Related Experiment Video
Updated: May 18, 2026
16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Functional and morphological changes in kidneys from marginal donors
B Borda1, E Szederkényi, P Szenohradszky
1Department of Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary. borda.bernadett@med.u-szeged.hu
Transplantation Proceedings
|September 15, 2012
Summary
Using marginal donor kidneys for transplantation leads to poorer graft function and more histological damage compared to ideal donors. Donor age and hypertension significantly impact kidney graft outcomes.
Area of Science:
- Nephrology
- Transplantation Immunology
- Organ Donation
Background:
- Organ transplantation faces a growing waiting list despite increased donor numbers.
- Marginal donor organs present a potential solution but require careful evaluation.
Purpose of the Study:
- To compare kidney graft outcomes between marginal and ideal donors.
- To assess the impact of donor age and hypertension on graft function and histology.
Main Methods:
- Retrospective analysis of kidney transplantations (n=63 marginal, n=86 ideal).
- Evaluation of donor/recipient data, graft function (serum creatinine, eGFR), and histology at 1 and 5 years.
- Comparison of outcomes based on donor characteristics (age >55, hypertension).
Main Results:
- Higher graft failure rates in marginal donor recipients (23 vs 39, P=.002).
- Significantly worse graft function (creatinine, eGFR) at 5 years for marginal donors (P=.0001, P=.003).
- Increased acute rejection and interstitial fibrosis/tubular atrophy in marginal donor kidneys (P=.0004, P=.002).
Conclusions:
- Marginal donor kidney transplantation yields inferior long-term graft function and histology.
- Donor age and hypertension are critical factors influencing graft deterioration.
- Careful donor selection is crucial to optimize kidney transplant outcomes.
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