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Related Experiment Videos

Topical propylene glycol and hyperosmolality.

C A Commens1

  • 1Skin and Cancer Foundation, Ashley Centre, Westmead, NSW, Australia.

The British Journal of Dermatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Topical propylene glycol is safe for adult dermatology patients. Studies show it does not affect serum osmolality, even with prolonged use in patients with skin disease.

Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Topical propylene glycol (PG) application can elevate serum osmolality in burn patients.
  • The safety of PG in dermatological practice requires further investigation.

Purpose of the Study:

  • To evaluate the effect of topical propylene glycol on serum osmolality in adult patients with skin disease.

Main Methods:

  • Twelve adult patients with skin disease received topical PG application.
  • Dosage was up to 6.1 g/kg per 24 hours for 5 days.
  • Serum electrolytes, lactate, and osmolality were monitored throughout the study.

Main Results:

  • Serum electrolyte levels remained stable.
  • Serum lactate levels showed no significant change.

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  • Serum osmolality did not increase during the study period.

    • Conclusions:

    • Topical propylene glycol can be safely used in adult dermatological practice.
    • The application of propylene glycol does not appear to affect serum osmolality in this patient group.