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Radial construction of an arterial wall
Daniel M Greif1, Maya Kumar, Janet K Lighthouse
1Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA. daniel.greif@yale.edu
Developmental Cell
|September 15, 2012
Summary
The pulmonary artery wall builds from the inside out through coordinated cell layer induction and migration. Radial signaling pathways, including PDGF-B, control this process and may impact arterial diseases.
Area of Science:
- Vascular biology
- Developmental biology
- Cardiovascular research
Background:
- Arterial wall diseases are linked to structural and size alterations.
- The assembly and patterning of arterial wall layers remain poorly understood.
- Understanding arterial wall development is crucial for disease insights.
Purpose of the Study:
- To elucidate the developmental mechanisms of pulmonary artery wall formation.
- To identify the cellular processes and signaling pathways involved in arterial wall construction.
Main Methods:
- Histochemical analysis in mice.
- Clonal analysis in mice.
- Genetic analysis in mice.
Main Results:
- The pulmonary artery wall is assembled radially, from the inside out.
- Two coordinated processes are involved: sequential mesenchyme induction and controlled cell invasion.
- Developmentally regulated cell reorientation and radial migration are key.
- A radial signal gradient, involving PDGF-B, controls these processes.
Conclusions:
- The arterial wall is built via a radial, inside-out process.
- Radial signaling pathways regulate arterial wall development.
- Modulation of these pathways may explain vessel-specific differences and pathological changes in arterial diseases.
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